Ernst-Lothar | Revolvy
Results at 37°C and 25°C 1 Ernst Moritz Arndt University, Greifswald, Germany; .. Correlation Critical Care , 14(Suppl 1):P23 (doi: /cc) was 1 Institute of Empirical Health Economic, Burscheid, Germany; 2Wyeth. Learn more about "Ernst-Lothar" on dubaiairporthotel.info Apel (–) Ernst Moritz Arndt (–) Achim von Arnim (–) Further complicating the family relations, her brother Herman was the third husband of Lutgard of Sa more. . of Jülich Metternich-Burscheid Lothar Friedrich von Metternich- Burscheid. 'Ernst MoritzArndt University, Greifswald, Germany; 2Dalhousie University, .. Analysis for correlation between ACR and VEGF-A in the sepsis patients (P ' Institute of Empirical Health Economic, Burscheid, Germany; 2Wyeth Pharma.
For catecholamine responsiveness, norepinephrine was applied 0.
NOx-levels in plasma were measured using high-pressure performing liquid chromatography. However, cardiac function and norepinephrine responsiveness were not improved compared with untreated septic WT. Conclusions Pharmacologic inhibition of nNOS result in significant reduction of plasma nitrate levels and prolonged survival compared with untreated septic WT despite unimproved septic cardiomyopathy.
Furthermore, the latter developed severe septic cardiomyopathy. In the glomerulus, it manifests as increased albumin excretion. Microalbuminuria is a common finding in various acute conditions like sepsis, trauma and surgery. Studies have shown increased levels of vascular endothelial growth factor-A VEGF-Aa potent vascular permeability inducing agent, in LPS-induced endotoxemia, severe sepsis and septic shock.
The pathogenic mechanism of the glomerular leakage of albumin in acute inflammatory conditions remains to be clarified.Was ist des Deutschen Vaterland ✠ [German patriotic song][+ english translation]
We wished to investigate the causative role of VEGF-A, in this regard which might have therapeutic implications. Methods Prospective study in the bed ICU of a tertiary care hospital.
Of these, 30 consecutive patients with sepsis, severe sepsis and septic shock sepsis group and 30 randomly chosen patients without sepsis were recruited for the VEGF-A study. Correlation was analyzed using Spearman's correlation coefficient. Results Sixty critically ill patients, with a median age IQR of 60 years 48 to 72 Conclusions Despite a strong physiologic rationale, our pilot study did not show an association between microalbuminuria and VEGF-A in critically ill patients. Larger studies are needed to come to a definitive conclusion.
Levels correlated with mortality in patients and anti-HMGB antibodies prevented endotoxin-induced death in animal models . Despite these reports, little is known of the role or mechanism of HMGB. We aimed to further evaluate HMGB in rat hearts and in pulmonary and renal cell cultures.
Left ventricular LV function was measured with a latex LV balloon. Infarct size was measured by TTC staining. Fluorimetric caspase-3 activity was used as measure of apoptosis. HMGB has anti-apoptotic effects that protect against hypoxic renal and alveolar cell injury.
We conclude that HMGB has potent anti-ischemic effects in multiple organs and may function as an innate cytoprotective mediator in sepsis. Tsung A, et al.: J Exp Med Kitahara T, et al.: Cardiovasc Res During sepsis a massive inflammatory activation occurs, which often leads to an important coagulation system dysfunction. PTX3 upregulates coagulation promoters in vitro . PTX3 may represent an early marker of severity and outcome and may be related to coagulation impairment in septic patients.
Methods We studied 90 patients affected by severe sepsis or septic shock previously enrolled in a prospective trial regarding the impact of glycemic control on inflammation and coagulation. We measured plasma PTX3 levels at enrollment and everyday until day 7. Mortality was recorded at day On day 1, septic shock patients had higher PTX3 levels than patients with severe sepsis Conclusions Persisting high levels of circulating PTX3 over the first days from sepsis onset may be associated with mortality.
PTX3 correlates with severity of sepsis and with sepsis-associated coagulation dysfunction. Mau ri T, et al.: Crit Care Med Na poleone E, et al.: J Leukoc Biol All rats were observed for behavioral changes for 24 hours after CLP operation. To show the alterations in BBB integrity, Evans blue EB; 69 kDa dye extravasation was determined for quantitative measurement of BBB permeability, and horseradish peroxidase HRP; 40 kDa extravasation was evaluated to provide ultrastructural evidence for the transport pathways involved in BBB permeability.
Immunohistochemistry was performed to show the alterations in immunoreactivity for tight junction protein occludin.
Both IgG and IgGAM alleviated the sickness behavior in septic rats and the animals were observed to be healthy and active.
Occludin immunoreactivity remained essentially unchanged in all groups including CLP. In addition, strong staining for HRP was seen around vessels located in the cerebral cortex and the hippocampus in septic animals. Increased luminal and abluminal vesicles containing electron-dense HRP reaction product were noted in the cytoplasm of endothelial cells in the cerebral cortex and hippocampus of septic rats, emphasizing an increased BBB permeability predominantly by transendothelial route.
In these animals, tight junctions were ultrastructurally intact suggesting that paracellular pathway of BBB is not responsible for the BBB breakdown in sepsis. Following IgG or IgGAM treatment, no ultrastructural evidence of leaky capillaries in brain was observed in septic animals indicating the blockade of the transcellular pathway.
Polyclonal intravenous immunoglobulins seem to be an interesting and useful option because of its activity in neutralizing endotoxin and in modulating the host immune response. In this retrospective study we assessed the effects of the early use of polyclonal intravenous immunoglobulins enriched with IgA-M IgGAM in addition to standard therapies on clinical outcome of patients with septic shock. From January to Septemberwe studied 52 consecutive patients with septic shock admitted to our ICU.
Conclusions These preliminary data indicate that the early use of IgGAM, associated with interventions proposed by the SSC guidelines, reduces mortality of patients with septic shock.
Ernst Moritz Arndt | German writer | dubaiairporthotel.info
Mechanism of action of intravenous immune serum globulin in autoimmune and inflammatory diseases. J Allergy Clin Immunol 1 Mirror, mirror on the wall, which is the fairest meta-analysis of all? Low levels of immunoglobulin G in patients with sepsis or septic shock: In a retrospective analysis of the data from the SBITS-trial  we investigated whether the initial level of serum IgG on admission to the hospital in patients with sepsis and septic shock before the first administration of the first dose of intravenous immunoglobulins could be seen as a prognostic parameter for the primary outcome, lethality on day 28, or the secondary endpoints, lethality on day 7 or on the ICU.
Methods A total of were included in the trial: The first group contained patients with a range in the IgG serum level up to 6. The second and third groups contained patients and patients, respectively, the immunoglobulin G levels were greater than 6.
The fourth group containing patients had IgG levels higher than Results On basis of this model we could show that lethality between the first and second groups did not differ significantly with the lethality in the third reference group with physiologic levels of IgG on day 0.
Surprisingly the lethality of the fourth group, with IgG levels higher than Conclusions Our post-hoc analysis did show no prognostic relevance of a low level of serum IgG on admission to hospital for the patients with sepsis and septic shock. Thus the initial serum level of IgG seems to be of no aid in making the decision to initiate therapy with intravenous immunoglobulins for these patients.
Whether a high level of serum IgG on admission is an independent risk factor for an increased lethality in critically ill patients, as shown in our analysis, needs to be investigated in further studies.
Werdan K, et al.: Score-based immunoglobulin G therapy of patients with sepsis: In the case of severe infectious disease, antibiotics are often supplemented with administration of IVIg.
The aim of this study is that the changes in sepsis markers followed by IVIg administration are investigated with severe sepsis or severe septic shock patients. Methods The subjects were 52 patients admitted to an ICU with a diagnosis of severe sepsis or septic shock and from whom informed consent had been obtained for the present study.
IVIg was administered intravenously for 3 days 5. The items measured were IL-6, C-reactive protein CRP and, as indices of vascular endothelial cell activation, plasminogen activator inhibitor-1 PAI-1 and adhesion molecules endothelial leukocyte adhesion molecule-1 ELAM-1 ; the effect of IVIg administration on these markers was then studied. The IVIg studied was polyethylene glycol-treated human immunoglobulin injection fluid 2. The values before IVIg administration were: All values were thus elevated.
Conclusions The results of the present study found significant decreases of IL-6 and PAI-1 resulting from immunoglobulin administration, but did not indicate a protective effect on vascular endothelial cell function.
The CRP level was higher in Q1 patients Prognostic value of B-type natriuretic peptide in critically ill patients with new onset of fever: Methods Thirty-one ICU patients 21 males and 10 females with new onset of fever and leukocytosis within the first 3 days of ICU admission were prospectively included in the study.
Exclusion criteria were heart or renal failure, chronic obstructive pulmonary disease and head trauma.
Ernst Moritz Arndt
Serial plasma samples were taken on days 1, 2 and 4 after the onset of fever for BNP level measurement. Results According to the clinical and laboratory findings within the first 3 days of hospitalization, the patients included in the study were divided into three groups: The optimal cutoff BNP value for differentiating between nonsurvivors and survivors was estimated to be The optimal cutoff BNP value for identifying these patients was estimated to be In patients with sepsis, a cut-off BNP value of Due to the small number of patients included in our study, further studies are needed to confirm these findings.
This study aimed to describe urinary albumin excretion in patients with septic shock and changes in microalbuminuria levels in the first 3 days of treatment. Methods Prospective observational study of 49 consecutive patients with septic shock admitted to a general ICU. Another sample of urine was collected on the third day of septic shock.
Microalbuminuria was measured by immunoturbidimetry with a limit of detection of 3.
The study was approved by the local Ethic Committee. Results The mean age was Observed mortality was The boldness of his demands for reform offended the Prussian government, and in the summer in he was arrested and his papers confiscated. Although speedily liberated, he was in the following year, at the behest of the Central Commission of Investigation at Mainz — established in accordance with the reactionary Carlsbad Decrees — arraigned before a special tribunal.
Although not found guilty, he was forbidden to exercise the functions of his professorship, although he was allowed to retain the stipend. The next 20 years he passed in retirement and literary activity.
The revolutionary outbreak of rekindled in the venerable patriot his old hopes and energies, and he took seat as one of the deputies to the National Assembly at Frankfurt. He participated in the deputation that offered the Imperial crown to Frederick William IVand was indignant at the king's refusal to accept it, so he retired from public life.
He continued to lecture and to write with freshness and vigor, and on his 90th birthday received from all parts of Germany good wishes and tokens of affection.
Ethnocentrism, antisemitism[ edit ] Originally a supporter of the ideas of the French revolution, Arndt dissociated himself from them when the Reign of Terror of the Jacobins became apparent. When Napoleon began to conquer Europe, this renunciation was transformed into visceral dislike.
Ernst Moritz Arndt - Wikipedia
His writings lack a specific political program, but instead cite external enemies. While "freedom" is often mentioned, the freedom Arndt envisioned was not that of a pluralistic society, but rather of a romanticized national community. The French are denigrated as weakened, womanish and morally depraved, while supposed German virtues are extolled. I could likewise say I hate the English presumption, the English prudery, the English seclusiveness.
These hated, despised, dispraised characteristics are not yet vices as such, from the peoples that they represent they may come with great virtues which I and my people are lacking.